Secondary resistance gene ccdB and repA2 facilitates carbapenem resistance in Escherichia coli carrying New Delhi Metallo-beta-lactamase

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New Delhi metallo-β-lactamase-producing carbapenem-resistant Escherichia coli associated with exposure to duodenoscopes.

IMPORTANCE Carbapenem-resistant Enterobacteriaceae (CRE) producing the New Delhi metallo-β-lactamase (NDM) are rare in the United States, but have the potential to add to the increasing CRE burden. Previous NDM-producing CRE clusters have been attributed to person-to-person transmission in health care facilities. OBJECTIVE To identify a source for, and interrupt transmission of, NDM-producing...

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New Delhi Metallo-β-Lactamase-Mediated Carbapenem Resistance: Origin, Diagnosis, Treatment and Public Health Concern

OBJECTIVE To review the origin, diagnosis, treatment and public health concern of New Delhi metallo-β-lactamase (NDM)-producing bacteria. DATA SOURCES We searched database for studies published in English. The database of PubMed from 2007 to 2015 was used to conduct a search using the keyword term "NDM and Acinetobacter or Enterobacteriaceae or Pseudomonas aeruginosa." STUDY SELECTION We co...

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First case of New Delhi metallo-beta-lactamase 1-producing Escherichia coli infection in Japan.

To the Editor—Emergence of multidrug-resistant organisms is a threat to public health, because there is limited effort devoted to the development of new antibiotics [1]. Multiple new mechanisms of resistance have been described recently, including a new type of carbapenem resistance gene, blaNDM-1, reported in 2009 [2]. Infections due to strains with blaNDM-1 have been reported in India, Pakist...

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Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance.

The rapidity with which new types of antibiotic resistance can disseminate globally following their initial emergence or recognition is exemplified by the novel carbapenemase New Delhi metallo-β-lactamase (NDM). The first documented case of infection caused by bacteria producing NDM occurred in 2008, although retrospective analyses of stored cultures have identified the gene encoding this enzym...

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Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae Producing New Delhi Metallo-Beta-Lactamase — Denver, Colorado, 2012

On August 16, 2012, the Colorado Department of Public Health and Environment was notified of two patients at an acute-care hospital in Denver with carbapenem-resistant Enterobacteriaceae (CRE), specifically Klebsiella pneumoniae (CRKP), isolated from respiratory specimens during July-August. Both isolates produced New Delhi metallo-beta-lactamase (NDM). A review of microbiology records identifi...

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ژورنال

عنوان ژورنال: International Journal of Infectious Diseases

سال: 2020

ISSN: 1201-9712

DOI: 10.1016/j.ijid.2020.09.129